Myeloid-specific fatty acid transport protein 4 deficiency induces a sex-dimorphic susceptibility for nonalcoholic steatohepatitis in mice fed a high-fat, high-cholesterol diet-Reference-Cited by-同舟云学术

Myeloid-specific fatty acid transport protein 4 deficiency induces a sex-dimorphic susceptibility for nonalcoholic steatohepatitis in mice fed a high-fat, high-cholesterol diet

Published:2023-05-01 Issue:5 Volume:324 Page:G389-G403
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Göcebe Deniz¹,Jansakun Chutima¹²^ORCID,Zhang Yuling¹^ORCID,Staffer Simone¹,Tuma-Kellner Sabine¹,Altamura Sandro³^ORCID,Muckenthaler Martina U.³⁴,Merle Uta¹^ORCID,Herrmann Thomas⁵,Chamulitrat Walee¹^ORCID

Affiliation:

1. Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany

2. School of Allied Health Sciences, Walailak University, Nakhonsrithammarat, Thailand

3. Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany

4. Translational Lung Research Center Heidelberg, German Center for Lung Research (DZL), German Centre for Cardiovascular Research, Partner Site, University of Heidelberg, Heidelberg, Germany

5. Westkuesten Hospital, Heide, Germany

Abstract

FATP4 deficiency in BMDMs and Kupffer cells led to increased proinflammatory response. Fatp4M−/− mice displayed thrombocytopenia, splenomegaly, and elevated liver enzymes. In response to HFHC feeding, male mutants were prone to hepatic steatosis, whereas female mutants showed exaggerated fibrosis. Our study provides insights into a sex-dimorphic susceptibility to NASH by myeloid-FATP4 deficiency.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00181.2022

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