Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse-Reference-Cited by-同舟云学术

Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse

Published:2023-02-01 Issue:2 Volume:324 Page:G115-G130
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Woods Crystal¹^ORCID,Flockton Amanda R.¹,Wallace Laurie E.²,Keenan Catherine M.²,Macklin Wendy B.³,Sharkey Keith A.²^ORCID,Belkind-Gerson Jaime¹⁴^ORCID

Affiliation:

1. Section of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado, Aurora, Colorado

2. Department of Physiology and Pharmacology, Cumming School of Medicine, Hotchkiss Brain Institute and Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

3. Department of Cell & Developmental Biology, University of Colorado, Aurora, Colorado

4. Neurogastroenterology and Motility Program, Digestive Health Institute, Children’s Hospital Colorado, Aurora, Colorado

Abstract

Here, we describe that Plp1 regulates gut motility and barrier function. The functional effects of Plp1 eradication are only seen in old mice, not young. The effects of Plp1 appear to be mediated through the Erk1/2 pathway.

Funder

Children's Hospital Colorado

Gouvernement du Canada | Canadian Institutes of Health Research

University of Colorado Anschutz Medical Campus

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00171.2022

Reference36 articles.

1. The enteric nervous system and neurogastroenterology