Long noncoding RNA LINC00982 upregulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY1-Reference-Cited by-同舟云学术

Long noncoding RNA LINC00982 upregulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY1

Published:2021-05-01 Issue:5 Volume:320 Page:G816-G828
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Zheng Lei¹,Cao Junlin¹,Liu Lijie¹,Xu Hongmei¹,Chen Lanlan¹,Kang Liying²,Gao Liming¹^ORCID

Affiliation:

1. Department of Oncology, the First Hospital of Qinhuangdao, Qinhuangdao, China

2. Department of Oncology, Wuqing People’s Hospital, Tianjin, China

Abstract

We identified LINC00982 as a promising antitumor target for the treatment of patients with gastric cancer. We also determined a regulatory network involved in the pathophysiology of gastric cancer wherein LINC00982 could bind to HEY1 to impair its binding to cathepsin F (CTSF) promoter and hence promote CTSF expression, which aids in better understanding of molecular mechanisms related to gastric tumorigenesis.

Funder

the Key R & D Project in Hebei Province

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00209.2020

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