Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency-Reference-Cited by-同舟云学术

Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency

Published:2021-06-01 Issue:6 Volume:320 Page:G969-G981
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Liu Yuying¹^ORCID,Hoang Thomas K.¹,Taylor Christopher M.²,Park Evelyn S.¹,Freeborn Jasmin¹,Luo Meng²,Roos Stefan³⁴,Rhoads J. Marc¹

Affiliation:

1. Division of Gastroenterology, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas

2. Department of Microbiology, Immunology and Parasitology, Louisiana State University School of Medicine, New Orleans, Louisiana

3. Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden

4. BioGaia AB, Stockholm, Sweden

Abstract

In the treatment of Treg-deficiency-induced autoimmunity, Limosilactobacillus reuteri DSM 17938 (LR) showed greater efficacy than Lacticaseibacillus rhamnosus GG (LGG). The study demonstrated that two different probiotics produce distinct signatures in the fecal microbial community in mice with Treg deficiency, but with many similarities in global plasma metabolites in general. However, there are strain-specific microbial products with different anti-inflammatory properties, reinforcing the concept that “one size does not fit all” in the treatment of autoimmune disease.

Funder

HHS | NIH | National Center for Complementary and Integrative Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00072.2021

Reference77 articles.

1. Special regulatory T cell review: How I became a T suppressor/ regulatory cell maven

2. The critical contribution of TGF-β to the induction of Foxp3 expression and regulatory T cell function