LPA<sub>5</sub>-Dependent signaling regulates regeneration of the intestinal epithelium following irradiation-Reference-Cited by-同舟云学术

LPA₅-Dependent signaling regulates regeneration of the intestinal epithelium following irradiation

Published:2024-06-01 Issue:6 Volume:326 Page:G631-G642
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

McConnell Beth B.¹^ORCID,Liang Zhongxing¹,Xu Chad¹,Han Yiran¹,Yun C. Chris¹²³^ORCID

Affiliation:

1. Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States

2. Gastroenterology Research, Atlanta Veterans Administration Medical Center, Decatur, Georgia, United States

3. Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States

Abstract

We used mice lacking expression of the lysophosphatidic acid receptor 5 (LPA5) in intestinal epithelial cells and intestinal organoids to show that the LPA5 receptor protects intestinal stem cells and progenitors from radiation-induced injury. We show that LPA5 induces YAP signaling and regulates Paneth cells.

Funder

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00269.2023

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