Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition-Reference-Cited by-同舟云学术

Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition

Published:2021-01-01 Issue:1 Volume:320 Page:G30-G42
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Her Ji Yun¹,Lee Yunna¹,Kim Su Jin¹,Heo Gwangbeom¹,Choo Jieun¹,Kim Yuju¹,Howe Cody²,Rhee Sang Hoon²,Yu Hak Sun³^ORCID,Chung Hae Young¹,Pothoulakis Charalabos⁴,Im Eunok¹^ORCID

Affiliation:

1. College of Pharmacy, Pusan National University, Busan, Republic of Korea

2. Department of Biological Sciences, Oakland University, Rochester, Michigan

3. Department of Parasitology and Tropical Medicine, School of Medicine, Pusan National University, Yangsan, Republic of Korea

4. Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California

Abstract

Deletion of PAR2 with high-fat diet feeding exacerbates colitis in a murine colitis model. Proinflammatory effects of PAR2 blockage in a high-fat environment were associated with an altered balance between autophagy and apoptosis. Increased colonic levels of PAR2 represent as a therapeutic strategy for IBD co-occurring with metabolic syndrome.

Funder

National Research Foundation of Korea

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00203.2020

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