Milk and Lacticaseibacillus paracasei BL23 effects on intestinal responses in a murine model of colitis

Author:

Bui Glory1,Torres-Fuentes Cristina12,Pusceddu Matteo M.3,Gareau Mélanie G.3ORCID,Marco Maria L.1

Affiliation:

1. Department of Food Science and Technology, University of California, Davis, Davis, California, United States

2. Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Tarragona, Spain

3. Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, California, United States

Abstract

Sex-dependent responses to probiotic Lacticaseibacillus paracasei and milk and the potential of the dairy matrix to enhance probiotic protection against colitis in this context have not been previously explored. Female mice were more sensitive than males to colonic injury, and neither treatment effectively alleviated inflammation in both sexes. These sex-dependent responses may result from differences in the higher baseline proportions of Akkermansia in the gut microbiome of female mice.

Funder

USDA | National Institute of Food and Agriculture

Publisher

American Physiological Society

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