Protease-activated receptor 2 drives migration in a colon cancer cell line but not in noncancerous human epithelial cells-Reference-Cited by-同舟云学术

Protease-activated receptor 2 drives migration in a colon cancer cell line but not in noncancerous human epithelial cells

Published:2024-05-01 Issue:5 Volume:326 Page:G525-G542
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Périco Larissa Lucena¹²,Vegso Andrew J.¹²,Baggio Cristiane H.¹²^ORCID,MacNaughton Wallace K.¹²^ORCID

Affiliation:

1. Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

2. Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

Abstract

Protease-activated receptor 2 enhances wound healing in the T84 colon cancer cell line, but not in primary cells derived from patient biopsies, an effect that is synergistically enhanced in the presence of the inflammatory cytokines TNF and IFNγ.

Funder

Canadian Government | Canadian Institutes of Health Research

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00284.2023

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