Characterization of hepatic inflammatory changes in a C57BL/6J mouse model of alpha1-antitrypsin deficiency-Reference-Cited by-同舟云学术

Characterization of hepatic inflammatory changes in a C57BL/6J mouse model of alpha1-antitrypsin deficiency

Published:2022-12-01 Issue:6 Volume:323 Page:G594-G608
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Khodayari Nazli¹^ORCID,Oshins Regina¹,Aranyos Alek M.¹,Duarte Sergio²,Mostofizadeh Sayedamin³,Lu Yuanqing¹,Brantly Mark¹^ORCID

Affiliation:

1. Division of Pulmonary, Department of Medicine, University of Florida, Gainesville, Florida

2. Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida

3. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida

Abstract

We have characterized a mouse model of human alpha-1 antitrypsin deficiency with a strong manifestation of liver disease that can be used as an in vivo tool to test preventive and therapeutic reagents. Our data explores the altered immunophenotype of alpha-1 antitrypsin-deficient liver macrophages and suggests a relationship between acute inflammation, immune response, and fibrosis.

Funder

Alpha-1 Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00207.2022

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