Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease-Reference-Cited by-同舟云学术

Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease

Published:2022-12-01 Issue:6 Volume:323 Page:G627-G639
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Araki Masaya¹,Nakagawa Yoshimi¹²³,Saito Hodaka²,Yamada Yasunari²,Han Song-Iee¹⁴,Mizunoe Yuhei¹,Ohno Hiroshi¹,Miyamoto Takafumi¹,Sekiya Motohiro¹,Matsuzaka Takashi¹⁵,Sone Hirohito⁶,Shimano Hitoshi¹³⁴⁷^ORCID

Affiliation:

1. Department of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

2. Division of Complex Biosystem Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama, Japan

3. Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Japan

4. International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan

5. Transborder Medical Research Center (TMRC), University of Tsukuba, Tsukuba, Japan

6. Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan

7. Japan Agency for Medical Research and Development–Core Research for Evolutional Science and Technology (AMED-CREST), Tokyo, Japan

Abstract

Hepatocyte- and macrophage-specific SREBP-1a knockout mice were generated for the first time. This study reveals that SREBP-1a does not contribute to hepatic lipogenesis, but in either hepatocytes or macrophages distinctly controls the onset of pathological conditions in methionine- and choline-deficient diet-induced hepatitis.

Funder

MEXT | Japan Society for the Promotion of Science

筑波大学 | Life Science Center for Survival Dynamics Tsukuba Advanced Research Alliance

Japan Agency for Medical Research and Development

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00090.2022

Reference44 articles.

1. Steatohepatitis: A tale of two “hits”?