Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model-Reference-Cited by-同舟云学术

Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model

Published:2022-04-01 Issue:4 Volume:322 Page:G431-G445
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Aghababaie Zahra¹,Cheng Leo K.¹²^ORCID,Paskaranandavadivel Niranchan¹^ORCID,Avci Recep¹^ORCID,Chan Chih-Hsiang Alexander¹^ORCID,Matthee Ashton¹,Amirapu Satya³,Asirvatham Samuel J.⁴,Farrugia Gianrico⁵^ORCID,Beyder Arthur⁵,O’Grady Gregory¹⁶^ORCID,Angeli-Gordon Timothy R.¹⁶^ORCID

Affiliation:

1. Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand

2. Department of Surgery, Vanderbilt University, Nashville, Tennessee

3. Histology Laboratory, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

4. Division of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota

5. Division of Gastroenterology and Hepatology and Enteric Neurosciences Program, Mayo Clinic, Rochester, Minnesota

6. Department of Surgery, University of Auckland, Auckland, New Zealand

Abstract

This study presents gastric ablation as a novel tool for modulating gastric bioelectrical activation, including eliminating the normal gastric pacemaker site as well as abnormal ectopic pacemaker sites underlying gastric dysrhythmias. Targeted application of radiofrequency ablation was able to eliminate these pacemaker sites without disrupting surrounding conduction capability or tissue structure. Gastric ablation presents a powerful new research tool for modulating gastric electrical activation and may likely hold therapeutic potential for disorders of gastric function.

Funder

Royal Society of New Zealand

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Center for Complementary and Integrative Health

Manatu Hauora | Health Research Council of New Zealand

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00332.2021

Reference52 articles.