Construction and validation of a rat model of acute necrotizing pancreatitis-associated intestinal injury-Reference-Cited by-同舟云学术

Construction and validation of a rat model of acute necrotizing pancreatitis-associated intestinal injury

Published:2024-07-01 Issue:1 Volume:327 Page:G80-G92
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Jiang Haojie¹²³,Xie Weidong¹²,Chen Qinbo²³,Li Yiling¹²,Yu Zhen¹²⁴,Liu Naxin¹²^ORCID

Affiliation:

1. Wenzhou Medical University, Wenzhou, People’s Republic of China

2. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China

3. Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, People’s Republic of China

4. Shanghai Tenth People’s Hospital, Shanghai, People’s Republic of China

Abstract

We constructed a rat model of acute necrotizing pancreatitis-associated intestinal injury and verified its feasibility. In addition, we identified the mechanism by which necrotic pancreatic tissue and pancreatitis-associated ascites fluid (PAAF) cause intestinal injury through the HIPPO signaling pathway.

Funder

MOST | NSFC | NSFC-Zhejiang Joint Fund | 浙江省科学技术厅 | Natural Science Foundation of Zhejiang Province

Wenzhou Municipal Science and Technology Bureau

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00262.2023

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