Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine-Reference-Cited by-同舟云学术

Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine

Published:2022-02-01 Issue:2 Volume:322 Page:G282-G293
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Walker Nancy M.¹,Liu Jinghua¹,Young Sarah M.¹²,Woode Rowena A.¹³,Clarke Lane L.¹³^ORCID

Affiliation:

1. Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri

2. Department of Pathobiology, University of Missouri, Columbia, Missouri

3. Department of Biomedical Sciences, University of Missouri, Columbia, Missouri

Abstract

Studies of small intestinal organoids from cystic fibrosis (CF) mice show that goblet cell hyperplasia and increased Toll-like receptor 2/4 expression are not primary manifestations of the CF intestine. Intestinal goblet cell hyperplasia in the CF mice was not strongly altered by genetic ablation of Tlr2 and Tlr 4, but could be induced in both wild-type and CF intestinal organoids by a Tlr2-dependent suppression of Notch signaling.

Funder

Cystic Fibrosis Foundation

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00290.2021

Reference77 articles.

1. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure

2. Gastrointestinal Outcomes and Confounders in Cystic Fibrosis