Albumin promoter-driven FlpO expression induces efficient genetic recombination in mouse liver-Reference-Cited by-同舟云学术

Albumin promoter-driven FlpO expression induces efficient genetic recombination in mouse liver

Published:2024-05-01 Issue:5 Volume:326 Page:G495-G503
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Zhu Xiaohui¹,Yang Yan¹,Feng Dongfeng¹,Wang Oliver¹,Chen Jiaxiang¹^ORCID,Wang Jiale¹^ORCID,Wang Bin¹,Liu Yang¹,Edenfield Brandy H.¹,Haddock Ashley N.¹,Wang Ying²,Patel Tushar³,Bi Yan⁴^ORCID,Ji Baoan¹^ORCID

Affiliation:

1. Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States

2. Departments of Cardiovascular Diseases and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States

3. Department of Transplantation, Mayo Clinic, Jacksonville, Florida, United States

4. Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, United States

Abstract

A liver-specific Alb-FlpO mouse line was generated. By coupling it with other existing CreERT or Cre lines, the dual recombinase approach can enable sequential gene modifications within the same cell or across various cell types in an organism for liver research through temporal and spatial gene manipulations.

Funder

HHS | NIH | National Cancer Institute

Mayo Clinic

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00263.2023

Reference40 articles.

1. Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

2. DNA excision in liver by an albumin-Cre transgene occurs progressively with age

3. "Cre"-ating mouse mutants---a meeting review on conditional mouse genetics

4. Conditional Gene Knockout Using Cre Recombinase

5. Cre activity in fetalalbCremouse hepatocytes: Utility for developmental studies

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