Revitalizing gut barrier integrity: role of miR-192-5p in enhancing autophagy via Rictor in enteritis-Reference-Cited by-同舟云学术

Revitalizing gut barrier integrity: role of miR-192-5p in enhancing autophagy via Rictor in enteritis

Published:2024-09-01 Issue:3 Volume:327 Page:G317-G332
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Qiu Peishan¹²,Zhou Kezhi¹²,Wang Youwei¹²,Chen Xiaoyu¹²,Xiao Cong¹²,Li Wenjie¹²,Chen Yuhua¹²,Chang Ying¹²,Liu Jing¹²,Zhou Feng¹²,Wang Xiaobing¹²,Shang Jian¹²,Liu Lan¹²,Qiu Zhao¹²^ORCID

Affiliation:

1. Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China

2. Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, China

Abstract

We uncover the pivotal role of miR-192-5p in fortifying intestinal barriers amidst inflammation. Reduced miR-192-5p levels correlated with compromised gut integrity during inflammation. Notably, boosting miR-192-5p reversed gut damage by enhancing autophagy via suppressing Rictor, offering a potential therapeutic strategy for fortifying the intestinal barrier and alleviating inflammation in patients with enteritis.

Funder

MOST | National Natural Science Foundation of China

Wuhan Municipal Science and Technology Bureau

Zhongnan Hospital of Wuhan University

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00291.2023

Reference56 articles.

1. Advances in IBD genetics

2. Unravelling the pathogenesis of inflammatory bowel disease

3. Cell death in the gut epithelium and implications for chronic inflammation

4. The intestinal epithelial barrier: a therapeutic target?

5. Regulation of Mammalian Autophagy in Physiology and Pathophysiology