Skeletal muscle protein turnover responses to parenteral nutrition in patients with alcoholic liver cirrhosis and sarcopenia-Reference-Cited by-同舟云学术

Skeletal muscle protein turnover responses to parenteral nutrition in patients with alcoholic liver cirrhosis and sarcopenia

Published:2023-08-01 Issue:2 Volume:325 Page:G174-G183
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Iepsen Ulrik Winning¹²^ORCID,Rinnov Anders Rasmussen¹^ORCID,Munch Gregers Winding¹,Rugbjerg Mette¹,Winding Kamilla Munch¹,Lauridsen Carsten³⁴,Berg Ronan M. G.¹⁵⁶⁷^ORCID,Pedersen Bente Klarlund¹,Gluud Lise Lotte⁸,van Hall Gerrit⁹¹⁰

Affiliation:

1. The Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

2. Department of Anaesthesiology and Intensive Care, Copenhagen University Hospital—Hvidovre Hospital, Copenhagen, Denmark

3. Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

4. Department of Technology, Copenhagen University College, Copenhagen, Denmark

5. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

6. Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

7. Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, United Kingdom

8. Gastro Unit, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark

9. Clinical Metabolomics Core Facility, Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark

10. Department of Biomedical Sciences, Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Abstract

Muscle protein turnover responses to parenteral nutritional (PN) supplementation have not previously been studied in stable alcoholic liver cirrhosis (ALC). We applied stable isotope tracers of amino acids to directly quantify net muscle protein turnover responses to PN in sarcopenic males with ALC and healthy controls. We found a higher net muscle protein gain in ALC during PN, thereby providing the physiological rationale for future clinical trials of PN as a potential countermeasure to sarcopenia.

Funder

A.P. Møller Fonden | Fonden til Lægevidenskabens Fremme

Aase og Ejnar Danielsens Fond

Augustinus Fonden

Direktør Jacob Madsen og Hustru Olga Madsens Fond

P. A. Messerschmidt og Hustrus Fond

TrygFonden

Danish National Research Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology