Expression of the regulated isoform of the electrogenic Na+/HCO3− cotransporter, NBCe1, is enriched in pacemaker interstitial cells of Cajal-Reference-Cited by-同舟云学术

Expression of the regulated isoform of the electrogenic Na+/HCO3− cotransporter, NBCe1, is enriched in pacemaker interstitial cells of Cajal

Published:2021-01-01 Issue:1 Volume:320 Page:G93-G107
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Colmenares Aguilar Maria-Gabriela¹,Mazzone Amelia¹,Eisenman Seth T.¹,Strege Peter R.¹,Bernard Cheryl E.¹,Holmes Heather L.²,Romero Michael F.²,Farrugia Gianrico¹³^ORCID,Gibbons Simon J.¹^ORCID

Affiliation:

1. Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota

2. Physiology and Biomedical Engineering, Nephrology and Hypertension, Mayo Clinic College of Medicine and Science, Rochester, Minnesota

3. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota

Abstract

In this study, we show that the electrogenic Na+/HCO3− cotransporter, NBCe1/Slc4a4, is expressed in subtypes of interstitial cells of Cajal (ICCs) responsible for electrical slow wave generation throughout the mouse gastrointestinal tract and is absent in other types of ICCs. The transcripts of Slc4a4 expressed in mouse ICCs and human gastrointestinal smooth muscle are the regulated isoforms. This indicates a key role for HCO3- transport in generation of gastrointestinal motility patterns.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00255.2020

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