GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration-Reference-Cited by-同舟云学术

GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration

Published:2021-04-01 Issue:4 Volume:320 Page:G531-G542
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Zhang Yuwei¹^ORCID,Zhou Xuefeng¹,Liu Peihao¹,Chen Xueyang¹,Zhang Jie¹,Zhang Hong¹,Li Sha¹,Chen Yishu¹,Song Xin¹,Wang Jinghua¹,Zeng Hang¹,Zhang Xiaofen¹,Tang Chenxi¹,Yu Chaohui¹,Li Youming¹,Xu Chengfu¹

Affiliation:

1. Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Abstract

We found GCSF was involved in lipid metabolism and NAFLD development. GCSF administration increased serum triglyceride levels in patients. GCSF deficiency alleviated HFD-induced insulin resistance and hepatic steatosis in mice. GCSF could directly act on hepatocytes through GCSFR-SOCS3-JAK-STAT3 pathway, and regulate the infiltration of immune cells into the liver to indirectly modulate NAFLD. Our finding indicates that GCSF may provide new strategies for the treatment of NAFLD.

Funder

national key research and development program

key research and development program of Zhejiang province

National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00342.2020

Reference42 articles.

1. The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study