hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223-Reference-Cited by-同舟云学术

hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223

Published:2020-12-01 Issue:6 Volume:319 Page:G703-G717
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Zhang Xiutian¹,Tan Peng²,Zhuang Yuan³,Du Lei⁴

Affiliation:

1. Department of Gastroenterology, Linyi People's Hospital, Linyi, China

2. Internal Medicine Teaching and Research Section, Shandong Medical College, Linyi, China

3. Histology and Embryology Teaching and Research Section, Shandong Medical College, Linyi, China

4. Department of Oncology, Linyi People's Hospital, Linyi, China

Abstract

Human circular (hsa_circ)RNA_001587 and solute carrier family 4 member 4 (SLC4A4) are poorly expressed, but microRNA (miR)-223 is overexpressed in pancreatic cancer (PC) cells. hsa_circRNA_001587 binds to miR-223. Overexpression of hsa_circRNA_001587 inhibits PC progression. Overexpression of miR-223 downregulates the expression of SLC4A4 and promotes PC cell growth. hsa_circRNA_001587 may be a potential target for PC treatment.

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00118.2020

Reference42 articles.

1. A novel strategy to enhance angiogenesis in vivo using the small VEGF-binding peptide PR1P

2. Bicarbonate transport in health and disease

3. Pancreatic cancer: yesterday, today and tomorrow

4. Dysregulation of key microRNAs in pancreatic cancer development

5. Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532–3p / FOXO4 axis

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