Duodenal-jejunal bypass improves nonalcoholic fatty liver disease independently of weight loss in rodents with diet-induced obesity-Reference-Cited by-同舟云学术

Duodenal-jejunal bypass improves nonalcoholic fatty liver disease independently of weight loss in rodents with diet-induced obesity

Published:2020-10-01 Issue:4 Volume:319 Page:G502-G511
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Angelini Giulia¹,Castagneto-Gissey Lidia²,Casella-Mariolo James³,Caristo Maria Emiliana¹,Russo Maria Francesca¹,Lembo Erminia¹,Verrastro Ornella¹,Stefanizzi Gianluigi¹,Marini Pier Luigi³,Casella Giovanni²,Bornstein Stefan R.⁴⁵,Rubino Francesco⁵,Mingrone Geltrude¹⁵

Affiliation:

1. Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Università Cattolica del S. Cuore, Rome, Italy

2. Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy

3. Department of Surgery, Azienda Ospedaliera S. Camillo Forlanini, Rome, Italy

4. Department of Medicine III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany

5. Diabetes and Nutritional Sciences, King's College London, London, United Kingdom

Abstract

Our findings suggest that duodenal-jejunal bypass can reverse, independently of weight loss, ectopic fat deposition and insulin resistance, two features of nonalcoholic fatty liver disease that share a mutual pathway, in which perilipin-2 seems to be the main player. Our study supports further investigation into the role of proximal small intestine exclusion in the pathophysiology of nonalcoholic fatty liver disease to uncover less invasive treatments that mimic the effects of metabolic surgery and aims to prevent and treat metabolic liver disease.

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00357.2019

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