Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis-Reference-Cited by-同舟云学术

Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis

Published:2021-06-01 Issue:6 Volume:320 Page:G958-G968
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Mizutani Naoki¹,Hikita Hayato¹,Saito Yoshinobu¹,Myojin Yuta¹,Sato Katsuhiko¹,Urabe Makiko¹,Kurahashi Tomohide¹,Shiode Yuto¹,Sakane Sadatsugu¹,Murai Kazuhiro¹,Nozaki Yasutoshi¹,Kodama Takahiro¹,Sakamori Ryotaro¹,Yoshida Yuichi¹,Tatsumi Tomohide¹,Takehara Tetsuo¹

Affiliation:

1. Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Abstract

Grb2-associated binder 1 (Gab1) is known to contribute to liver regeneration after acute liver injury. However, in chronic liver diseases, Gab1 plays a greater role in suppressing hepatocyte apoptosis than in liver regeneration, resulting in suppression of hepatocyte proliferation, liver fibrosis, and liver carcinogenesis.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00370.2020

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