Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity-Reference-Cited by-同舟云学术

Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity

Published:2022-09-01 Issue:3 Volume:323 Page:G157-G164
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Hashem Anas Mohamad¹^ORCID,Cifuentes Lizeth¹^ORCID,Calderon Gerardo¹,Ricardo-Silgado Maria Laura¹,Gonzalez-Izundegui Daniel¹,Campos Alejandro¹,McRae Alison¹,Franks Shawna¹,Hurtado Maria Daniela¹²,Burton Duane¹,Petterson Xuan-Mai³,Lanza Ian R.³⁴^ORCID,Camilleri Michael¹^ORCID,Acosta Andres¹^ORCID

Affiliation:

1. Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota

2. Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic Health System, La Crosse, Wisconsin

3. Metabolomics Core Laboratory, Mayo Clinic, Rochester, Minnesota

4. Endocrinology Research Unit, Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, Minnesota

Abstract

We show how switching from a regular diet to an HCHF increases cholesterol absorption in patients with normal weight and obesity. The decrease in cholesterol absorption from an HCHF to an LCLF, on the other hand, was only seen in normal-weight controls, underlining the importance of body weight in this regulation. In addition, changes in caloric and fat content had an immediate and direct effect on hepatic bile acid production.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00108.2022

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