Assessment of the role of FGF15 in mediating the metabolic outcomes of murine vertical sleeve gastrectomy-Reference-Cited by-同舟云学术

Assessment of the role of FGF15 in mediating the metabolic outcomes of murine vertical sleeve gastrectomy

Published:2020-12-01 Issue:6 Volume:319 Page:G669-G684
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Myronovych Andriy¹²^ORCID,Bhattacharjee Jashdeep³,Salazar-Gonzalez Rosa-Maria¹³,Tan Brandon¹,Mowery Sarah¹,Ferguson Danielle¹,Ryan Karen K.⁴,Zhang Wujuan⁵,Zhao Xueheng⁵,Oehrle Melissa⁵,Setchell Kenneth D. R.⁵,Seeley Randy J.²,Sandoval Darleen A.²,Kohli Rohit¹³^ORCID

Affiliation:

1. Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

2. Department of Surgery, University of Michigan, Ann Arbor, Michigan

3. Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital Los Angeles, Los Angeles, California

4. Department of Neurobiology, Physiology and Behavior, University of California, Davis, California

5. Department of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

Abstract

In the absence of an intact fibroblast growth factor 15 (FGF15) signaling pathway, murine vertical sleeve gastrectomy results in weight loss without all its anticipated metabolic benefits. In the absence of an intact FGF15 signaling pathway, vertical sleeve gastrectomy results in increased intestinal bile acid levels and hepatolipotoxicity.

Funder

Ethicon Endo-Surgery

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00175.2020

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1. An FXR Agonist Reduces Bile Acid Synthesis Independently of Increases in FGF19 in Healthy Volunteers

2. Bariatric Surgery and Endoluminal Procedures: IFSO Worldwide Survey 2014