Transcriptomic identification of TMIGD1 and its relationship with the ileal epithelial cell differentiation in Crohn’s disease-Reference-Cited by-同舟云学术

Transcriptomic identification of TMIGD1 and its relationship with the ileal epithelial cell differentiation in Crohn’s disease

Published:2020-08-01 Issue:2 Volume:319 Page:G109-G120
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Zabana Yamile¹²,Lorén Violeta¹²^ORCID,Domènech Eugeni¹²³,Aterido Adrià⁴⁵,Garcia-Jaraquemada Arce¹,Julià Antonio⁴,Vicario Maria²⁶,Pedrosa Elisabet¹,Ferreiro Miriam¹,Troya José⁷,Lozano Juan J.²,Sarrias Maria R.²⁸^ORCID,Cabré Eduard¹²³,Mañosa Miriam¹²³,Manyé Josep¹²

Affiliation:

1. IBD Research Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Catalonia, Spain

2. Centro de Investigación Biomédica en Red (CIBER), Madrid, Spain

3. Gastroenterology Department, Germans Trias i Pujol University Hospital, Badalona, Catalonia, Spain

4. Rheumatology Research Group, Vall d’Hebron Research Institute, Barcelona, Catalonia, Spain

5. Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain

6. Laboratory of Translational Mucosal Immunology & Department of Gastroenterology, Digestive Diseases Research Unit, Vall d’Hebron Research University Hospital, Badalona, Catalonia, Spain

7. Colorectal Surgery Unit, General and Digestive Surgery Department, Germans Trias i Pujol University Hospital, Badalona, Catalonia, Spain

8. Innate Immunity Group, IGTP (AGAUR 2017-SGR-490 group), Badalona, Catalonia, Spain

Abstract

This is a single-center translational research study that aimed to look for key targets involved in Crohn’s disease and define molecular pathways through different functional analysis strategies. With this approach, we have identified and described a novel target, the almost unknown TMIGD1 gene, which may be key in the recovery of injured mucosa involving intestinal epithelial cell differentiation.

Funder

Ministry of Economy and Competitiveness | Instituto de Salud Carlos III

Centro de Investigación Biomédica en Red

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00027.2020

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