Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice-Reference-Cited by-同舟云学术

Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice

Published:2021-06-01 Issue:6 Volume:320 Page:G936-G957
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Marincola Smith Paula¹²^ORCID,Choksi Yash A.³⁴,Markham Nicholas O.³⁵⁶,Hanna David N.¹,Zi Jinghuan¹,Weaver Connie J.¹,Hamaamen Jalal A.¹,Lewis Keeli B.¹,Yang Jing⁷⁸,Liu Qi⁷⁸,Kaji Izumi¹⁵,Means Anna L.¹²⁶⁹¹⁰,Beauchamp R. Daniel¹²⁵⁶⁹^ORCID

Affiliation:

1. Section of Surgical Sciences, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee

2. Graduate Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee

3. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

4. Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee

5. Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee

6. Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, Tennessee

7. Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, Tennessee

8. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee

9. Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee

10. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee

Abstract

We demonstrate that canonical TGFβ family signaling modulates the expression of critical tight junction proteins in colon epithelial cells, and that expression of these tight junction proteins is associated with maintenance of colon epithelial barrier function in mice.

Funder

Burroughs Wellcome Fund

HHS | NIH | Office of Extramural Research, National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00053.2021

Reference109 articles.

1. Loss of Smad5 leads to the disassembly of the apical junctional complex and increased susceptibility to experimental colitis