FXR deletion attenuates intestinal barrier dysfunction in murine acute intestinal inflammation-Reference-Cited by-同舟云学术

FXR deletion attenuates intestinal barrier dysfunction in murine acute intestinal inflammation

Published:2024-08-01 Issue:2 Volume:327 Page:G175-G187
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

O’Guinn MaKayla L.¹²,Handler David A.¹²,Hsieh Jonathan J.¹³⁴,Mallicote Michael U.¹²⁴,Feliciano Karina¹²,Gayer Christopher P.¹²⁴^ORCID

Affiliation:

1. The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California, United States

2. Division of Pediatric Surgery, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, California, United States

3. Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, United States

4. Department of Biochemistry and Molecular Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States

Abstract

Intestinal barrier failure is a hallmark in gut-origin sepsis. We demonstrate that the intestinal barriers of farnesoid-X receptor (FXR) knockout (KO) animals are protected from inflammatory insult using multiple models of acute intestinal inflammation. This protection is due to decreased inflammatory cytokine production and maintenance of tight junctional architecture seen within the KO animals. This is the first report of FXR deletion being protective to the intestinal barrier.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00063.2024

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