Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease-Reference-Cited by-同舟云学术

Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease

Published:2021-09-01 Issue:3 Volume:321 Page:G308-G324
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Girish Nandini¹²,Liu Cambrian Y.¹³,Gadeock Safina¹²,Gomez Marie L.⁴,Huang Ying¹,Sharifkhodaei Zohreh¹²,Washington M. Kay⁵,Polk D. Brent¹²⁴⁶^ORCID

Affiliation:

1. Division of Pediatric Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California

2. Division of Pediatric Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, UC University of California San Diego School of Medicine, San Diego, California

3. Department of Medicine, The University of Chicago, Chicago, Illinois

4. Department of Biochemistry & Molecular Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California

5. Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee

6. Department of Pediatrics, Keck School of Medicine of the University of Southern California, Los Angeles, California

Abstract

Acute intestinal injury and epithelial repair are associated with the loss of fast-cycling Lgr5+ stem cells and plasticity in the activation of formerly quiescent cell populations. In contrast, here we show in murine inflammatory bowel disease the persistence of the Lgr5+ stem cell population and its essential role in restricting the severity of chronic colitis. This demonstrates a diversity of stem cell responses to colitis.

Funder

Crohn's and Colitis Foundation

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00248.2020

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1. Identification of stem cells in small intestine and colon by marker gene Lgr5

2. Intestinal label-retaining cells are secretory precursors expressing Lgr5