Tumor DDR1 deficiency reduces liver metastasis by colon carcinoma and impairs stromal reaction-Reference-Cited by-同舟云学术

Tumor DDR1 deficiency reduces liver metastasis by colon carcinoma and impairs stromal reaction

Published:2021-06-01 Issue:6 Volume:320 Page:G1002-G1013
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Romayor Irene¹^ORCID,Márquez Joana¹,Benedicto Aitor¹,Herrero Alba¹,Arteta Beatriz¹,Olaso Elvira¹

Affiliation:

1. Tumor Microenvironment Group, Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain

Abstract

Tumor DDR1 acts as a key factor during the desmoplastic response surrounding hepatic colorectal metastasis. Hepatic sinusoidal cell-derived soluble factors stimulate tumor DDR1 activation. DDR1 modulates matrix remodeling to promote metastasis in the liver through the interaction with hepatic stromal cells, specifically liver sinusoidal endothelial cells and hepatic stellate cells.

Funder

University of the Basque Country

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00078.2021

Reference50 articles.

1. Colorectal liver metastases: Current management and future perspectives

2. Patterns of metastasis in colon and rectal cancer

3. The role of liver microenvironment in hepatic metastasis

4. Microenvironment and tumor cell plasticity: An easy way out

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Multifaceted collagen-DDR1 signaling in cancer;Trends in Cell Biology;2023-09

2. A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance;Scientific Reports;2023-04-08

3. Focusing on discoidin domain receptors in premalignant and malignant liver diseases;Frontiers in Oncology;2023-03-15

4. Deciphering the possible reciprocal loop between hepatic stellate cells and cancer cells in the tumor microenvironment of the liver;Critical Reviews in Oncology/Hematology;2023-02

5. New target DDR1: A “double-edged sword” in solid tumors;Biochimica et Biophysica Acta (BBA) - Reviews on Cancer;2023-01