Affiliation:
1. Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 481 and Centre Claude Bernard de Recherches sur les Hépatites Virales, Hôpital Beaujon, 92118 Clichy, France
Abstract
Rich diet and lack of exercise are causing a surge in the prevalence of obesity and hepatic steatosis, which causes “primary” steatohepatitis in some patients. Ultrastructural mitochondrial lesions, decreased activity of respiratory chain complexes, and impaired ability to synthesize ATP are observed in these patients. Reactive oxygen species (ROS) may increase tumor necrosis factor-α (TNF-α) production and also oxidize fat deposits. TNF-α and lipid peroxidation products impair the flow of electrons along the respiratory chain, causing overreduction of respiratory chain components and enhanced mitochondrial ROS formation. Steatohepatitis can also be due to alcohol, drugs, or other causes that either directly increase ROS formation or first impair respiration, which secondarily increases ROS formation. Higher ROS formation in secondary steatohepatitis could cause more lipid peroxidation, cytokine induction, and fibrogenesis than in primary steatohepatitis.
Publisher
American Physiological Society
Subject
Physiology (medical),Gastroenterology,Hepatology,Physiology
Cited by
237 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献