Pregnancy-related plasticity of gastric vagal afferent signals in mice-Reference-Cited by-同舟云学术

Pregnancy-related plasticity of gastric vagal afferent signals in mice

Published:2021-02-01 Issue:2 Volume:320 Page:G183-G192
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Li Hui¹²^ORCID,Clarke Georgia S.¹²³,Christie Stewart¹²,Ladyman Sharon R.⁴,Kentish Stephen J.¹²,Young Richard L.¹²,Gatford Kathryn L.¹²³^ORCID,Page Amanda J.¹²^ORCID

Affiliation:

1. Adelaide Medical School, University of Adelaide, Adelaide, Australia

2. Nutrition, Diabetes and Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, Australia

3. Robinson Research Institute, University of Adelaide, Adelaide, Australia

4. Department of Anatomy, Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand

Abstract

This study provides first evidence that gastric vagal afferent signaling is attenuated during pregnancy and inversely associated with meal size. Growth hormone attenuated mechanosensitivity of gastric vagal afferents, adding support that increases in maternal growth hormone may mediate adaptations in gastric vagal afferent signaling during pregnancy. These findings have important implications for the peripheral control of food intake during pregnancy.

Funder

Robinson Research Institute, University of Adelaide

The University of Adelaide

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00357.2020

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