Parallel intermediate conductance K+ and Cl− channel activity mediates electroneutral K+ exit across basolateral membranes in rat distal colon-Reference-Cited by-同舟云学术

Parallel intermediate conductance K+ and Cl− channel activity mediates electroneutral K+ exit across basolateral membranes in rat distal colon

Published:2020-08-01 Issue:2 Volume:319 Page:G142-G150
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Rehman Shabina¹,Narayanan Karthikeyan¹,Nickerson Andrew J.¹²,Coon Steven D.³,Hoque Kazi Mirajul⁴,Sandle Geoffrey I.⁵,Rajendran Vazhaikkurichi M.¹⁶^ORCID

Affiliation:

1. Departments of Biochemistry West Virginia University School of Medicine, Morgantown, West Virginia

2. Departments of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia

3. Department of Biological Sciences, Port Peck Community College, Poplar, Montana

4. Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland

5. Leeds Institute for Medical Research at St. James’s, St. James’s University Hospital. Leeds, United Kingdom

6. Departments of Medicine, West Virginia University School of Medicine, Morgantown, West Virginia

Abstract

This study demonstrates that during active electroneutral K+ absorption in rat distal colon, K+ exit across the basolateral membrane mainly reflects intermediate conductance K+ channels operating in conjunction with chloride channel 2, with a smaller but significant contribution from K+-Cl− cotransporter-1 activity.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00011.2020

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