Characteristics of mesenteric adipose tissue attached to different intestinal segments and their roles in immune regulation

Author:

Zhang Haowei123ORCID,Ding Yujin12,Zeng Qin12,Wang Dandan12,Liu Ganglei4,Hussain Zain5,Xiao Boen6,Liu Wei6,Deng Tuo127

Affiliation:

1. National Clinical Research Center for Metabolic Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China

2. Key Laboratory of Diabetes Immunology, Ministry of Education, and Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha, China

3. Department of Orthopedics, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China

4. Department of Geriatric Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, China

5. Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas

6. Department of Biliopancreatic Surgery and Bariatric Surgery, The Second Xiangya Hospital, Central South University, Changsha, China

7. Clinical Immunology Center, The Second Xiangya Hospital of Central South University, Changsha, China

Abstract

Our results change the paradigm of how we regard MAT as a contiguous and homogeneous tissue to an intensely heterogeneous tissue. Appreciation of the differences between regional MATs will guide future research to investigate the specialized roles of different MATs in intestinal health and disease.

Funder

National Key Research and Development Program of China

National Science and Technology Major Project

Science and Technology Program of Hunan Province

National Natural Science Foundation of China

Innovation-Driven Project of Central South University

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

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