Urolithin A attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling-Reference-Cited by-同舟云学术

Urolithin A attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling

Published:2022-10-01 Issue:4 Volume:323 Page:G375-G386
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Mehra Siddharth¹,Srinivasan Supriya¹,Singh Samara¹,Zhou Zhiqun¹,Garrido Vanessa¹,Silva Iago De Castro¹,Totiger Tulasigeri M.¹,Dosch Austin R.¹,Dai Xizi¹,Dawra Rajinder K.¹²,Jala Venkatakrishna Rao³,Shi Chanjuan⁴,Datta Jashodeep¹²,VanSaun Michael⁵,Merchant Nipun¹²,Nagathihalli Nagaraj¹²^ORCID

Affiliation:

1. Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida

2. Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida

3. Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky

4. Department of Pathology, Duke University School of Medicine, Durham, North Carolina

5. Department of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas

Abstract

Our novel findings presented here demonstrate the utility of Uro A as an effective therapeutic agent in attenuating alcoholic chronic pancreatitis (ACP) severity with alcohol continuation after established disease, through suppression of the PI3K/AKT/mTOR signaling pathway.

Funder

Sylvester Comprehensive Cancer Center (SCCC), University of Miami

Florida Department of Health

HHS | NIH | National Cancer Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00159.2022

Reference44 articles.

1. Chronic pancreatitis, a comprehensive review and update. Part I: Epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features