Affiliation:
1. Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People’s Republic of China
Abstract
Intestinal perfusion of UAG, the unacylated form of ghrelin, has shown promising potential for treating MAFLD. This study unveils a potential mechanism involving the central GLP-1 pathway, with UAG upregulating GLP-1R expression and activating GLP-1 neurons in specific brain regions. These findings propose a novel therapeutic strategy for MAFLD treatment through UAG and its modulation of the GLP-1 neuronal pathway.
Funder
Shandong Provincial Natural Science Foundation
Innovative Training Program for College Students of Shandong Province
Publisher
American Physiological Society