Flupirtine enhances NHE-3-mediated Na+ absorption in rat colon via an ENS-dependent mechanism-Reference-Cited by-同舟云学术

Flupirtine enhances NHE-3-mediated Na+ absorption in rat colon via an ENS-dependent mechanism

Published:2021-08-01 Issue:2 Volume:321 Page:G185-G199
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Nickerson Andrew J.¹²,Rajendran Vazhaikkurichi M.²³^ORCID

Affiliation:

1. Departments of Physiology, Pharmacology and Neuroscience, West Virginia University School of Medicine, Morgantown, West Virginia

2. Department of Biochemistry, West Virginia University School of Medicine, Morgantown, West Virginia

3. Department of Medicine, West Virginia University School of Medicine, Morgantown, West Virginia

Abstract

We present a novel mechanism regarding regulation of epithelial ion transport by enteric neurons. Activation of neuronal KV7 K+ channels markedly stimulates Na+ absorption and inhibits Cl− secretion across the colonic epithelium. This may be useful in developing new treatments for diarrheal disorders, such as irritable bowel syndrome with diarrhea (IBS-D).

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00158.2021

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