Control of colonic motility using electrical stimulation to modulate enteric neural activity-Reference-Cited by-同舟云学术

Control of colonic motility using electrical stimulation to modulate enteric neural activity

Published:2021-04-01 Issue:4 Volume:320 Page:G675-G687
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Barth Bradley B.¹^ORCID,Travis Lee²,Spencer Nick J.²^ORCID,Grill Warren M.¹³⁴⁵^ORCID

Affiliation:

1. Department of Biomedical Engineering, Duke University, Durham, North Carolina

2. Visceral Neurophysiology Laboratory, College of Medicine and Public Health, Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia

3. Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina

4. Department of Neurobiology, Duke University, Durham, North Carolina

5. Department of Neurosurgery, Duke University, Durham, North Carolina

Abstract

Maintained physiological distension of the isolated mouse colon induces rhythmic cyclic myoelectric complexes (MCs). MCs evoked repeatedly by closed-loop electrical stimulation entrain MCs more frequently than spontaneously occurring MCs. Electrical stimulation delivered at the onset of a contraction temporarily suppresses the propagation of MC contractions. Controlled electrical stimulation can either evoke MCs or temporarily delay MCs in the isolated mouse colon, depending on timing relative to ongoing activity.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00463.2020

Reference35 articles.

1. The enteric nervous system and neurogastroenterology

2. Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility