Experimental analysis of T cell epitopes for designing liver cancer vaccine predicted by system-level immunoinformatics approach-Reference-Cited by-同舟云学术

Experimental analysis of T cell epitopes for designing liver cancer vaccine predicted by system-level immunoinformatics approach

Published:2020-06-01 Issue:6 Volume:318 Page:G1055-G1069
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Muhammad Syed Aun¹,Zafar Sidra¹,Rizvi Samana Zahra¹,Imran Imran²,Munir Fahad³,Jamshed Muhammad Babar³⁴^ORCID,Ali Amjad⁵,Wu Xiaogang⁶,Shahid Numan⁷,Zaeem Muhammad⁴,Zhang Qiyu³

Affiliation:

1. Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan

2. Faculty of Pharmacy, Department Pharmacology, Bahauddin Zakariya University, Multan, Pakistan

3. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China

4. School of Pharmaceutical Sciences of Wenzhou Medical University, Wenzhou, People’s Republic of China

5. Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan

6. The University of Texas MD Anderson Cancer Center, Houston, Texas

7. Department of General Surgery, The School of International Studies of Wenzhou Medical University, Wenzhou, People’s Republic of China

Abstract

We observed substantial high levels of granzymes B in serum samples of component C6 (C6) and albumin (ALB) compared with control, indicating the activity of cytotoxic T cells. We concluded that C6 and ALB are likely to contain potential epitopes for the induction of protective effector molecules, supporting the feasibility of therapeutic peptide-based vaccine for liver cancer.

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00068.2020

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