Non-TGFβ profibrotic signaling in ulcerative colitis after in vivo experimental intestinal injury in humans-Reference-Cited by-同舟云学术

Non-TGFβ profibrotic signaling in ulcerative colitis after in vivo experimental intestinal injury in humans

Published:2024-07-01 Issue:1 Volume:327 Page:G70-G79
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Seidelin Jakob B.¹²^ORCID,Bronze Mariana¹³⁴,Poulsen Anja¹²,Attauabi Mohamed¹²^ORCID,Woetmann Anders³⁴,Mead Benjamin E.⁵⁶⁷⁸⁹,Karp Jeffrey M.⁵⁷⁸¹⁰¹¹,Riis Lene B.¹²,Bjerrum Jacob T.¹

Affiliation:

1. Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

2. Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

3. Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark

4. LEO Foundation Skin Immunology Research Center, University of Copenhagen, Copenhagen, Denmark

5. Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

6. Koch Institute for Integrative Cancer Research; Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

7. Harvard Stem Cell Institute, Cambridge, Massachusetts, United States

8. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, United States

9. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

10. Harvard Medical School, Boston, Massachusetts, United States

11. Department of Anesthesiology, Perioperative and Pain Medicine,Brigham and Women’s Hospital, Cambridge, Massachusetts, United States

12. Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

Abstract

The study reveals the regulatory dynamics of epithelial regeneration and extracellular matrix remodeling after experimental injury of the human colon in vivo and shows that human intestinal regeneration is different from data obtained from animals. A lag phase in epithelial restitution is associated with induction of stromal cell-derived epithelial growth factors. Postinjury regeneration is transforming growth factor β-independent, and we find a profibrotic response in patients with ulcerative colitis despite being in remission.

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00074.2024

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