<i>Nfkb2</i> deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa-Reference-Cited by-同舟云学术

Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa

Published:2022-10-01 Issue:4 Volume:323 Page:G306-G317
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Papoutsopoulou Stamatia¹²^ORCID,Tang Joseph¹,Elramli Ahmed H.¹³,Williams Jonathan M.¹⁴,Gupta Nitika¹,Ikuomola Felix I.¹,Sheibani-Tezerji Raheleh⁵,Alam Mohammad T.⁶⁷,Hernández-Fernaud Juan R.⁶⁸,Caamaño Jorge H.⁹,Probert Chris S.¹,Muller Werner¹⁰,Duckworth Carrie A.¹,Pritchard D. Mark¹^ORCID

Affiliation:

1. Institute of Systems, Molecular and Integrative Biology, Faculty of Health & Life Sciences, University of Liverpool, Liverpool, United Kingdom

2. Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, Larissa, Greece

3. Department of Basic Medical Sciences, Faculty of Dentistry, University of Benghazi, Benghazi, Libya

4. Pathobiology and Population Sciences, The Royal Veterinary College, Hatfield, United Kingdom

5. Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Kiel, Germany

6. Warwick Medical School, Bioinformatics RTP, University of Warwick, Coventry, United Kingdom

7. Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates

8. Unidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, La Laguna, Spain

9. College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

10. Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

Abstract

Novel transcriptomic analysis of murine proximal intestinal mucosa revealed an unexpected B cell signature in Nfkb2−/− mice. In-depth analysis revealed a defect in the CD38+ B cell population and a gut-specific dysregulation of immunoglobulin levels.

Funder

University of Liverpool

Embassy of Libya

EC | FP7 | Capacities | FP7 International Cooperation

Wellcome Trust

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00037.2022

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