Arm lean mass determined by dual-energy X-ray absorptiometry is superior to characterize skeletal muscle and predict sarcopenia-related mortality in cirrhosis

Author:

Eriksen Christian Skou1,Kimer Nina2,Suetta Charlotte345,Møller Søren1

Affiliation:

1. Center of Functional Imaging and Research, Department of Clinical Physiology and Nuclear Medicine, Hvidovre University Hospital, Copenhagen, Denmark

2. Gastro Unit, Medical Division, Hvidovre University Hospital, Copenhagen, Denmark

3. Geriatric Research Unit, Department of Geriatrics and Palliative Medicine, Bispebjerg and Frederiksberg University Hospitals, Copenhagen, Denmark

4. Geriatric Research Unit, Department of Medicine, Herlev and Gentofte University Hospitals, Copenhagen, Denmark

5. Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet-Glostrup, University of Copenhagen, Copenhagen, Denmark

Abstract

Sarcopenia increases mortality in patients with end-stage liver disease. We show that arm lean mass determined by dual-energy X-ray absorptiometry is a better marker than the traditional appendicular skeletal muscle mass when predicting sarcopenia-related mortality in patients with cirrhosis of different severity. The findings add to the dispute about the optimal method for repeated assessments of skeletal muscle status in patients with cirrhosis and may have implications for clinical decision making.

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

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