MAPK p38/Ulk1 pathway inhibits autophagy and induces IL-1β expression in hepatic stellate cells-Reference-Cited by-同舟云学术

MAPK p38/Ulk1 pathway inhibits autophagy and induces IL-1β expression in hepatic stellate cells

Published:2022-03-01 Issue:3 Volume:322 Page:G360-G367
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Jin Li¹^ORCID,Li Juan¹,Yang ShuJuan¹²,Zhang Rou¹^ORCID,Hu ChunHua¹,Chen Yi¹,Tian Zhen¹^ORCID,Ma WenQi³,Feng YaLi¹,Liu Na¹⁴,Liu JinFeng¹⁵,Yang Yuan¹⁵,Chen TianYan¹⁵,Zhao YingRen¹⁵,He YingLi¹⁵^ORCID,Yan TaoTao¹⁵

Affiliation:

1. Institution of Hepatology, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, China

2. The Eighth Hospital, Xi’an, Shaanxi, China

3. Department of Ultrasound, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

4. Department of Infectious Diseases, Yan’an University Affiliated Hospital, Yan’an, Shaanxi, China

5. Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, China

Abstract

LPS inhibits autophagy in a concentration- and dose-dependent manner in HSC-T6 cells. MAPK p38 induces phosphorylation of Ulk1, which disrupts the Ulk1-Atg13 complex and is therefore required for the inhibition of autophagy by LPS. LPS induces IL-1β expression via the MAPK p38/Ulk1 pathway in HSCs.

Funder

NSFC | Major Research Plan

NSFC | Young Scientists Fund

Natural Science Foundation of Shaanxi Province

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00230.2021

Reference24 articles.

1. Mechanisms of fibrosis in acute liver failure