Endogenous glucocorticoids are required for normal macrophage activation and gastric <i>Helicobacter pylori</i> immunity-Reference-Cited by-同舟云学术

Endogenous glucocorticoids are required for normal macrophage activation and gastric Helicobacter pylori immunity

Published:2024-10-01 Issue:4 Volume:327 Page:G531-G544
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Khadka Stuti¹,Dziadowicz Sebastian A.¹,Xu Xiaojiang²,Wang Lei¹,Hu Gangqing¹,Carrero Javier A.³,DiPaolo Richard J.³,Busada Jonathan T.¹^ORCID

Affiliation:

1. Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, West Virginia, United States

2. Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States

3. Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States

Abstract

Signaling by endogenous glucocorticoids primes macrophages toward more robust responses to pathogens. Disruption of glucocorticoid signaling caused dysregulation of the chromatin landscape, blunted proinflammatory gene activation upon bacterial challenge, and impaired the gastric inflammatory response to Helicobacter pylori infection.

Funder

HHS | National Institutes of Health

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00114.2024

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