Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3-Reference-Cited by-同舟云学术

Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3

Published:2022-01-01 Issue:1 Volume:322 Page:G93-G106
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Han Huajun¹²^ORCID,Davidson Laurie A.¹³,Fan Yang-Yi¹³,Landrock Kerstin K.¹³,Jayaraman Arul⁴,Safe Stephen H.⁵,Chapkin Robert S.¹²³^ORCID

Affiliation:

1. Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, Texas

2. Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas

3. Department of Nutrition, Texas A&M University, College Station, Texas

4. Department of Chemical Engineering, Texas A&M University, College Station, Texas

5. Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas

Abstract

AhR is a key transcription factor controlling expression of IL22 in gut immune cells. In this study, we show for the first time that AhR signaling also regulates IL22 response in colonic epithelial cells by modulating SOCS3 expression.

Funder

Cancer Prevention and Research Institute of Texas

HHS | NIH | National Institute of Environmental Health Sciences

HHS | NIH | National Cancer Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00074.2021

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1. Therapeutic opportunities of the IL-22–IL-22R1 system