Water intake accelerates ATP release from myofibroblast cells in rats: ATP-mediated podoplanin-dependent control for physiological function and immunity-Reference-Cited by-同舟云学术

Water intake accelerates ATP release from myofibroblast cells in rats: ATP-mediated podoplanin-dependent control for physiological function and immunity

Published:2021-01-01 Issue:1 Volume:320 Page:G54-G65
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Hayashi Moyuru¹²,Watanabe-Asaka Tomomi¹²,Nagashio Sachiho¹,Kaidoh Maki¹,Yokoyama Yumiko¹,Maejima Daisuke¹,Kajihara Ryo¹³,Amari Kei¹³,Arai Nariaki¹⁴,Kawai Yoshiko¹²,Ohhashi Toshio¹^ORCID

Affiliation:

1. Department of Innovation of Medical and Health Sciences Research, Shinshu University School of Medicine, Matsumoto, Japan

2. Division of Physiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan

3. Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Japan

4. Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Japan

Abstract

We investigated effects of shear stress stimulation on cultured myofibroblast cells and water intake on podoplanin and IL-22 expressions in rat jejunal villi. The stimulation induced ATP release from the cells. Water intake accelerated podoplanin and IL-22 expression levels. ATP increased IL-22 mRNA expression in innate lymphoid cells (ILC)-3. Hence, water intake maintains higher osmotic pressure in the jejunal villi through ATP release and podoplanin upregulation. Water intake may regulate the mucosal immunity.

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00303.2020

Reference38 articles.

1. Water intake increases mesenteric lymph flow and the total flux of albumin, long-chain fatty acids, and IL-22 in rats: new concept of absorption in jejunum

2. Microcirculation of the alimentary tract

3. Guyton AC, Taylor A, Grange HJ. Circulatory Physiology II. Dynamics and Control of Body Fluids. Philadelphia, PA: Sanders, 1975, p. 125–160.

4. The regulatory niche of intestinal stem cells

5. The Pericryptal Fibroblast Sheath

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