Myotomy technique and esophageal contractility impact blown-out myotomy formation in achalasia: an in silico investigation-Reference-Cited by-同舟云学术

Myotomy technique and esophageal contractility impact blown-out myotomy formation in achalasia: an in silico investigation

Published:2022-05-01 Issue:5 Volume:322 Page:G500-G512
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Halder Sourav¹^ORCID,Acharya Shashank²^ORCID,Kou Wenjun³,Campagna Ryan A. J⁴,Triggs Joseph R.⁵,Carlson Dustin A.³,Aadam Abdul Aziz³,Hungness Eric S.⁴,Kahrilas Peter J.³,Pandolfino John E.³,Patankar Neelesh A.¹²^ORCID

Affiliation:

1. Theoretical and Applied Mechanics Program, McCormick School of Engineering, Northwestern University, Evanston, Illinois

2. Department of Mechanical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois

3. Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

4. Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

5. Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

Blown-out myotomy (BOM) is a complication observed after myotomy, which is performed to treat achalasia. In silico simulations were performed to identify the factors leading to BOM formation. We found that a short myotomy that is not transmural and has some structural architecture intact reduces the risk of BOM formation. In addition, we found that high esophagogastric junction tone due to fundoplication is found to increase the risk of BOM formation.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

National Science Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00281.2021

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