An opioid receptor-independent mechanism underlies motility dysfunction and visceral hyperalgesia in opioid-induced bowel dysfunction-Reference-Cited by-同舟云学术

An opioid receptor-independent mechanism underlies motility dysfunction and visceral hyperalgesia in opioid-induced bowel dysfunction

Published:2021-06-01 Issue:6 Volume:320 Page:G1093-G1104
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Lin You-Min¹,Tang Yanbo¹²,Fu Yu¹,Hegde Shrilakshmi¹,Shi Daniel W.¹³,Huang Li-Yen M.⁴,Shi Xuan-Zheng¹

Affiliation:

1. Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas

2. Department of Gastroenterology, The First Affiliated Hospital, Guangxi University of Science and Technology, Guangxi, China

3. College of Science, Texas A&M University, College Station, Texas

4. Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas

Abstract

Our preclinical study shows that fecal retention is a pathogenic factor in opioid-induced bowel dysfunction, as prevention of fecal retention with liquid diet improved motility and attenuated visceral hyperalgesia in morphine-treated animals by blocking expression of cyclooxygenase-2 and nerve growth factor in the colon.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Defense

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00400.2020

Reference54 articles.

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