Renal concentration in the normal dog: effect of an acute reduction in salt excretion

Author:

Goodman Berney1,Cohen Jay A.1,Levitt Marvin F.1,Kahn Melvin1

Affiliation:

1. Section of Renal Diseases, Department of Medicine, The Mount Sinai Hospital, New York City

Abstract

In normal anesthetized hydropenic dogs, the TcH2O-Cosm relation generated by infusing hypertonic solutions was variable. In ten dogs TcH2O rose as Cosm increased, attaining a maximum of 3.7–6.3 ml/min ("high curve"). In seven dogs a maximum TcH2O of only 1.4–2.5 ml/min was observed at low Cosm and CH2O was often generated at moderate Cosm ("low curve"). The acute reproducibility of this TcH2O-Cosm relation was examined by allowing Cosm to return to low levels and again infusing the same hypertonic solution. The TCH2O-Cosm relation was duplicated only in dogs initially exhibiting a high curve. Therefore, the effects on TcH2O of acutely reduced sodium excretion were examined only in dogs with an initial high curve relation. After the first diuresis, a phlebotomy or prolonged infusion of 10% mannitol was utilized to induce salt retention. If sodium excretion was reduced to less than 40 µEq/min at low Cosm, TcH2O was decreased during the subsequent diuresis. This impairment in TcH2O generation is attributed to decreased availability of salt for transport into the medulla.

Publisher

American Physiological Society

Subject

Physiology (medical)

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