Specificity of mammalian kallidinogen

Abstract

Hog pancreas kallikrein does not cause a blood pressure drop in the rat, but lowers the blood pressure in the dog. Since this lack of effect could be due to the inability of hog pancreas kallikrein to act upon rat plasma, the in vitro release of kallidin with the plasma of different species was studied. Human, dog, swine, rat, guinea pig, and ox plasmas were incubated for different periods of time with hog pancreas kallikrein, and the bradykininogen (kallidinogen) consumed and the kallidin released were measured. It was found that hog pancreas kallikrein does not release any kallidin with rat and guinea pig plasma; it releases small amounts with pig plasma and greater amounts with bovine, dog, and human plasma. The bradykininogen consumption showed the same sequence.