Canine gastric blood flow and its distribution

Abstract

Total gastric blood flow in the dog as estimated by the K42 clearance technique agreed within 5% with measured total venous outflow. Extraction of the isotope by the stomach was found to be such that 30–60 sec following injection the organ contained a fraction of the injected dose that was the same as the fraction of the cardiac output that perfused the organ. By comparison with the radioactive microsphere method, the K42 clearance technique was also found to be reasonably accurate for determination of the distribution of the total flow within the organ. Mean total gastric blood flow in intact dogs, unoperated upon except for femoral arterial and venous catheterization, was 49 ml/min per organ or 0.54 ml/min per gram. This was distributed 80% to corpus and 20% to antrum. The corpus flow was partitioned among the mural tissues: mucosa 72%, submucosa 13%, and muscle serosa 15%.