Distribution of alloxan-C14 in islet and other tissues of the toadfish (Opsanus tau)

Author:

Cooperstein S. J.1,Lazarow Arnold1

Affiliation:

1. Department of Anatomy, Western Reserve University School of Medicine, Cleveland, Ohio, Department of Anatomy, University of Minnesota School of Medicine, Minneapolis, Minnesota, and Marine Biological Laboratory, Woods Hole, Massachusetts

Abstract

These studies on the mechanism by which alloxan selectively destroys the ß cells in the islets of Langerhans have been carried out in the toadfish because the islet tissue in this species is segregated into a discrete mass, separated from the acinar tissue. We have measured the C14 content of several tissues at various times after intravenous injection of tracer doses of alloxan-2-C14. The islet C14 content never exceeded 50% of that of blood and was no greater than that found in many other tissues. Thus the selectivity of alloxan is not due to selective concentration by islet tissue. The distribution of alloxan-2-C14 was compared with that of d-mannitol-1-H3. A mixture of both isotopic substances was injected and the C14 and H3 in each tissue determined. The distribution of alloxan-2-C14 was very similar to that of d-mannitol-1-H3. This suggests that tracer doses of injected alloxan do not enter islet cells but remain in the extracellular compartment, and that the ß-cell membrane may be a primary site of alloxan action.

Publisher

American Physiological Society

Subject

Physiology (medical)

Cited by 43 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3